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Contact information
Postal address:
Institute of Problems of Chemical Physics RAS,
Prosp. akad. N.N.Semenova, 1, Chernogolovka, Moscow region,
142432, Russia.
Phone: +7 (496-52) 2-77-79
Fax: +7 (496-52) 2-35-07
E-mail: alexei@icp.ac.ru
Education/Degrees
Sep. 1986 – Jul.1993: Nizhny Novgorod State Univercity;
Faculty of Biology, Biochemistry and Plant Physiology Department, M. Sc.,
Diploma, Nizhny Novgorod, Russia;
Jan. 1994 – Dec. 1997: Post-graduate at the Institute of
Problems of Chemical Physics of Russian Academy of Sciences, Chernogolovka,
Russia;
Doctorate: Dec. 1998: Ph.D. degree in Biophisics an
Biochemistry, PhD thesis: "Structural Reorganization of Chromatin of
Hepatocytes in the Process of Transcription Activation and Inactivation of
Protooncogenes c-Fos and c-Myc", Institute of Chemical Physics RAS, Moscow.
Positions
Sep. 1993-Dec. 1997: Post-graduate student, Institute of
Problems of Chemical Physics RAS, Chernogolovka, Russia;
Jan. 1998-Apr. 1999: Junior researcher, Institute of
Problems of Chemical Physics RAS, Chernogolovka, Russia;
May 1999 – Jul. 2001: Postdoctoral fellow, Ludwig
Institute for Cancer Research, the Uppsala Branch, Uppsala, Sweden;
Aug. 2001 – Apr. 2002: Senior researcher, Institute of
Problems of Chemical Physics RAS, Chernogolovka, Russia;
Apr. 2002 – present: Head of the Molecular Biology
Laboratory, Institute of Problems of Chemical Physics RAS, Chernogolovka,
Russia.
Scientific interests
Cell cycle regulation, cell death regulation.
Cytotoxicity ant its molecular pathways, role of the tumor suppressor p53
and the antioxidant system.
Antitumor compounds, cytotoxicity (structure-activity
relations), cellular pathways and molecular mechanisms of cytotoxicity.
Nuclear architecture. Chromatin structure and the nuclear
matrix. Role of chromatin in transcription regulation.
Publications
Boikov P.Ia., Kostiuk G.V.,
Terent'ev A.A., Shevchenko N.A. [Concentrating proto-oncogenes in hepatocyte
nuclei] // Molecular Biology (Moscow). 1995, 29(5):1137-44. [Article in
Russian]
Terent'ev A.A. [Regulatory
pathways of the c-fos proto-oncogene] // Biokhimiia. 1995, 60(12):1923-1952.
[Article in Russian]
Terent'ev A.A, Kostyuk G.V.,
Boikov P.Y. Changes in structural organization of the nucleosome fiber
during protooncogene activation // Biochemistry (Moscow). 1998,
63(2):149-154.
Alesenko A.V., Solov'ev A.S.,
Terent'ev A.A., Khrenov A.V. [The role of sphingomyelin cycle products in
development of apoptosis mediated by Fas receptors and tumor necrosis factor
alpha] // Izv Akad Nauk Ser Biol. 1998, (2):157-166.
[Article
in
Russian]
Terent'ev A.A., Kostyuk G.V.,
Boikov P.Y. Dynamics of association-dissociation of the c-myc gene with the
nuclear matrix during activation-inactivation of the gene // Biochemistry
(Moscow). 1998, 63(5):533-536.
Globa A.G., Solovyev A.S.,
Terentyev A.A., Demidova V.S., Shulgina M.F., Alesenko A.V., Karelin A.A.
TNF alpha-induced aerobic synthesis of ATP on plasma membranes of target
cells. The relation to the expression of the nuclear oncogene c-myc. //
Biochemistry and Molecular Biology International. 1998. Vol.45, Iss.6,
P.1169-1178.
Borisova N.P., Kostyuk G.V.,
Shevchenko N.A., Boikov P.Y., Rudakova E.V., Papina R.I., Terent'ev A.A.
Functional association of immediate early gene c-fos with nuclear matrix //
Bulletin of Experimental Biology and Medicine. 2003, 135(2):167-170.
Borisova
N.P.,
Kostyuk
G.V.,
Shevchenko
N.A.,
Boikov P.Y.,
Rudakova
E.V.,
Papina
R.I,.
Terent'ev A.A. Dual
effects of endogenous DNases on transcriptionally active and inactive
chromatin // Bulletin of Experimental Biology and Medicine. 2003,
135(3):253-257.
Kurisaki
K.,
Kurisaki
A.,
Valcourt
U.,
Terentiev
A.A.,
Pardali
K.,
Ten
Dijke P.,
Heldin
C.H.,
Ericsson
J.,
Moustakas
A.
Nuclear
factor YY1
inhibits
transforming
growth
factor
beta-
and
bone morphogenetic
protein-induced
cell
differentiation.
// Molecular
and
Cellular
Biology. 2003,
23(13):4494-4510.
Borisova
N.P.,
Kostiuk
G.V.,
Shevchenko
N.A.,
Boikov
P.Ia.,
Rudakova
E.V.,
Papina
R.I.,
Terent'ev A.A.
[Endogenous
DNases
as
a tool
for
isolation
of nuclear
matrix:
critical
parameters
of nucleolysis]
// Izvestiia
Akademii
Nauk.
Seria Biologicheskaia.
2003, 5:534-541. [Article in Russian].
Grönroos E., Terentiev A.A.,
Punga T., Ericsson J. YY1 inhibits the activation of the p53 tumor
suppressor in response to genotoxic stress. // Proceedings of the National
Academy of Sciences of the USA. 2004, 101(33):12165–12170.
Lapshina MA, Parkhomenko II,
Terentiev AA. Two forms
of the nuclear matrix-bound p53 protein in HEK293 cells. // Annals of the
New York Academy of Sciences. 2006, 1090:177-181.
Beljkov
A.P.,
Chubarova
G.D.,
Terentiev
A.A.,
Samylina
I.A.,
Sorokina
A.A.,
Iljichev
A.V.,
Maljdov
D.G.
[The role
of
alkaloids
in
antitumor
activity
of
aconite
tinctures] // Farmaciia.
2008, 4:46-47. [Article
in Russian].
Lapshina M.A., Parkhomenko I.I.,
Papina R.I., Terentiev A.A. Lamin B content in chromatin fractions after
purification of nuclear matrix from cells of different types // Bulletin of
Experimental Biology and Medicine. 2008, 146(5):580-584.
Iljichev
A.V.,
Maljdov
D.G.,
Chubarova
G.D.,
Beljkov
A.P.,
Arzamascev
E.V.,
Malinovskaia
K.I.,
Lapshina
M.A.,
Boltneva
N.P.,
Terentiev
A.A.,
[Toxicity
and
antitumor
effect of
of
aconite
tinctures]
// Farmaciia.
2009, 2:28-32. [Article
in Russian].
Rajewskaya
T.A.,
Goncharova
S.A.,
Konovalova
N.P.,
Terent'ev A.A.,
Lapshina
M.A.
Effect
of
nitric
oxide
donor,
a
modulator
of tumor
drug
resistance, on
cell
death
and p53
protein
expression
// Bulletin
of Experimental
Biology
and Medicine.
2009, 147(4):421-423.
Kabachkov
E.N.,
Kurkin E.N.,
Nadtochenko V.A.,
Terentyev A.A.
[Investigation of
photocatalytic
degradation
of
tumor
cells on
titanium
dioxide
with
Fourier
transform
infrared
spectroscopy]
// High Energy
Chemistry.
2010, 44(5):458-462. [Article
in Russian].
Kabachkov
E.N.,
Kurkin E.N.,
Nadtochenko V.A.,
Terentyev A.A.
Research
of
photocatalytic
degradation of
HeLa
cells at
the
TiO2
interface by ATR-FTIR
and fluorescence
microscopy. Journal of Photochemistry and Photobiology A: Chemistry. 2010,
217(2-3):425–429.
Derevkova V.A., Balalaeva I.V.,
Papina R.I., Korepin A.G., Glushakova N.M., Terent’ev A.A. Cytostatic action
of triazole and oxazolidinone derivatives // Russian Chemical Bulletin.
2011, 60(6), In press.
Stupina T.S., Parkhomenko I.I.,
Balalaeva I.V., Kostyuk G.V., Sanina N.A., Terent’ev A.A. Cytotoxic activity
of nitrosyl iron complex with thiophenolyl // Russian Chemical Bulletin.
2011, 60(7), In press.
Senj V.D., Terent’ev A.A.,
Konovalova N.P. Synthesis, interaction with DNA, and antitumor activity of
platinum complexes with aminonitroxyl radicals // Russian Chemical Bulletin.
2011, 60(7), In press.
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