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Anticancer drugs
 

 
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Dr. Bhuvaneshwar Vaidya

 

Department of Pharmaceutics

ISF College of Pharmacy,

Moga (Punjab) India

 

 

 

Research Interest

 

SCIENTIFIC INTEREST

·       Synthesis and design of polymeric nanocarriers for the delivery of drug/gene to tumor

·       Designing of nanocarriers for combination therapy of cancer

·       Designing of nanocarriers for the delivery of cell survival pathways inhibitors for the treatment of chemoresistant cancer

·       Functionalization of nanocarriers for different biomedical applications

·       Development of novel carriers for the delivery of drugs for complicated disease like cardiovascular disease

·       Oral delivery of anticancer agents

·       Bioavailability enhancement using novel carrier systems

 

 

Publications

Research articles

1.   Kumar L., Verma S. Jamwal S., Vaidya S and Vaidya B. Polymeric microparticles based formulation for the eradication of cutaneous candidiasis: Development and characterization. Pharm Dev Tech, 2013 (In press)

                                                                                                                                         

2.   Vaidya B. and Vyas S. P. Transferrin coupled vesicular system for intracellular delivery for the treatment of cancer: Development and Characterization. J Drug Target, 2012; 20(4): 372-80.     

3.   Vaidya B., Agrawal GP and Vyas SP. Platelets directed liposomes for the delivery of streptokinase: Development and characterization. Eur J Pharma Sci. 2011; 44(5): 589-94.                          

4.   Vaidya B, Nayak MK, Dash D, Agrawal GP, Vyas SP Development and characterization of site specific target sensitive liposomes for the delivery of thrombolytic agents. Int J Pharm 2011, 203(1-2): 254-261.

                                                                                                                                                    

5.   Vaidya B, Goyal AK, Khatri K, Mishra N, Paliwal R, Rai S, Tiwari S., Vyas SP, Bolaamphiphiles Based Novel Liposomes: A Possible Approach for Drug Delivery, Int. J. Biomed. Nanoscience Nanotech. 2010, 1: 95-108.

 

6.   Vaidya B, Paliwal R, Rai S, Khatri K, Goyal AK, Mishra N, Vyas SP Cell-selective mitochondrial targeting: A new approach for cancer therapy. Cancer Therapy, 2009, 7A: 141-148.  

7.   Tiwari S, Goyal A, Mishra N, Katri K., Mehta A, Vaidya B, Wu Y., Vyas S.P. Development and characterization of novel carrier gel core liposomes based transmission blocking malaria vaccine J. Control Release 2009; 140(2):157-65.                                                                                                  

8.   F. Zakir, B. Vaidya, A.K. Goyal, B. Malik, S.P. Vyas Development and characterization of oleic acid vesicles for the topical delivery of fluconazole. Drug Deliv, 2010; 17(4):238-48.                

9.   N. Mishra, S. Tiwari, B. Vaidya, G.P. Agrawal, S.P. Vyas Lectin Anchored PLGA Nanoparticles for Oral Mucosal Immunization against Hepatitis B J Drug Target, 2011; 19(1): 67-78.       

    

10.        D. Pawar, A. K. Goyal, S. Mangal, N. Mishra, B. Vaidya, S. Tiwari, A. K. Jain, S. P. Vyas. Evaluation of Mucoadhesive PLGA Microparticles for Nasal Immunization. The AAPS Journal, 2009 12(2):130-7.       

                                                                                                                                         

11.        A. K. Jain, A. K. Goyal, N. Mishra, B. Vaidya, S. Mangal, S. P. Vyas. PEG–PLA–PEG block copolymeric nanoparticles for oral immunization against hepatitis B. Int J Pharm, 2009 387(1-2):253-62.                                                                                                                                                        

12.        Rai S, Paliwal R, Vaidya B, Khatri K, Gupta PN, Goyal AK and Vyas SP. Targeted delivery of doxorubicin via estrone appended liposomes. J Drug Target, 2008 16(6); 455-463.             

 

13.        Goyal AK, Khatri K, Mishra N, Mehta A, Vaidya B, Tiwari S, Paliwal R, Paliwal S, and Vyas SP. Development of Self-assembled Nanoceramic Carrier Construct(s) for Vaccine Delivery. J. Biomat Appl, 2009 24(1):65-84.                                                                                                                    

 

14.        Goyal AK, Khatri K, Mishra N, Mehta A, Vaidya B, Tiwari S and Vyas SP Aquasome: A novel approaches for the delivery of antigen. Drug Dev Ind Pharm 2008 34: 1297-1305.             

15.        Paliwal R, Rai S, Vaidya B, Gupta PN, Khatri K, Goyal AK, Mishra N, Mehta A, and Vyas SP Effect of Lipid Core Material on Characterstics of Solid Lipid Nanoparticles Designed for Oral Lymphatic Delivery Nanomedicine: Nanotechnology, Biology and Medicine, 2008 5(2):184-91.                              

 

16.        M. Gupta, A.K Goyal, S.R. Paliwal, R. Paliwal, N. Mishra, B. Vaidya, D. Dube, S.K. Jain, S.P. Vyas Development and Characterization of Effective Topical Liposomal System for Localized Treatment of Cutaneous Candidiasis. J Liposome Res, 2010; 20(4): 341-50.                                           

17.        F. Zakir, H. Sharma, K. Kaur, B. Malik, B. Vaidya, A.K. Goyal, S. P. Vyas Nanocrystallization of Poorly Water Soluble Drugs for Parenteral Administration. J. Biomed. Nanotechnol. 2011; 7:127-129.        

 

18.        M. Gupta, B. Vaidya, N. Mishra, S. P. Vyas Effect of surfactants on the characteristics of fluconazole niosomes for enhanced cutaneous delivery. Artificial cells, Blood substitutes, and biotechnology, 2011,39: 376-84.                                                                                                                                       

 

Review articles

1.           Kumar K., Dhawan N., Sharma H, Vaidya S, Vaidya B. Bioadhesive polymers: Novel tool for drug delivery. Artificial cells, Nanomedicine, and Biotechnology, 2013 (In press)                               

 

2.           Kumar L., Verma S., Bhardwaj A., Vaidya S. and Vaidya B. Eradication of superficial fungal infection by conventional and novel approach: A comprehensive review. Artificial cells, Nanomedicine, and Biotechnology, 2013 (In press)                                                                                           

 

3.           Vaidya B., Agrawal GP and Vyas SP. Functionalized carriers for the improved delivery of plasminogen activators. Int J Pharm 2011, 424;1-11.                                                           

4.           Vaidya B, Mishra N, Dube D, Tiwari S, Vyas SP Targeted nucleic acid delivery to mitochondria. Curr Gene Therapy 2009, 9, 475-486.                                                                                      

5.       Vays SP and Vaidya B. Targeted delivery of thrombolytic agents: Role of integrin receptors. Exp Opin Drug Deliv, 2009, 6(5), 499-508.                                                                                  

6.       Rawat A, Vaidya B, Khatri K, Goyal AK, Gupta PN, Mahor S, Paliwal R, Rai S, Vyas SP. Targeted intracellular delivery of therapeutics: An overview. Die Pharmazie. 2007; 62(9):643-58.    

 

7.       Paliwal R, Rai S, Vaidya B, Mahor S, Gupta PN, Rawat A, Vyas SP (2007) Cell-Selective Mitochondrial Targeting: Progress in Mitochondrial Medicine. Curr Drug Del. 2007;4(3):211-24.    

 

8.       Mishra N, Goyal AK, Khatri K, Vaidya B, Paliwal R, Rai S, Mehta A, Tiwari S, Vyas S, Vyas SP, Biodegradable polymer based particulate carrier(s) for the delivery of proteins and peptides Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7(4); 240-251.                                 

        

9.   Rai S, Paliwal R, Vaidya B, Gupta, P N., Mahor S, Khatri K, Goyal A K., Rawat A, Vyas SP. Estrogen(s) and Analogs as a Non-Immunogenic Endogenous Ligand in Targeted Drug/ DNA Delivery. Curr. Medicinal Chem. 2007 14(19): 2095-109.                                                                                            

10.        Rai S, Paliwal R, Gupta PN, Khatri K, Goyal AK, Mahor S, Vaidya B, Vyas SP. Solid lipid nanoparticles (SLNs) as a rising tool in drug delivery science:  one step up in nanotechnology. Current Nanoscience, 2008 4(1): 30-44.                                                                                  

11.    N. Mishra, A.K. Goyal, S. Tiwari, R. Paliwal, S.R. Paliwal, B. Vaidya, D. Dube, M. Gupta, A. Mehta, S. Mangal, S.P. Vyas Recent advances in mucosal delivery of vaccines: Role of mucoadhesive/biodegradble polymeric carriers Expert Opin Ther patents, 2010 20(5), 661-679.                    

 

Full papers in Conferences proceedings

1.           Tiwari S, Goyal A, Mishra N, Katri K., Vaidya B, Mehta A, Wu Yimin, Vyas S.P. Liposomes in situ gelling system: Novel carrier based vaccine adjuvant for intranasal delivery of recombinant protein vaccine Procedia in vaccinology, 2009, 1, 148-163.                                                                            

2.           Vaidya B., Vaidya S, Chandy A, Ahirwar D, Phytosomes: A step ahead in the field of phytomedicine, National Seminar on Potential approaches in herbaceuticals, 27-29 March 2009 Organized by School of Pharmacy, CEC, Bilaspur.

 

Chapter in books

Indian Books:

1.           Vaidya B, Rawat A, Vyas SP. Virosome: a promising carrier for cytosolic delivery of therapeutic(s), in: Nanocolloidal carriers: sire specific and controlled drug delivery, CBS Publishers and distributors, New Delhi, 2010.

2.           Vyas SP, Vaidya B. Nanocarriers: recent developments and potential applications in drug delivery, in: Nanocolloidal carriers: sire specific and controlled drug delivery, CBS Publishers and distributors, New Delhi, 2010.

3.       Zakir F, Vaidya B, Malik B, Vyas SP. Fatty acid vesicles: promising drift in colloidal drug carriers, in: Nanocolloidal carriers: sire specific and controlled drug delivery, CBS Publishers and distributors, New Delhi, 2010.

4.       Vyas SP, Vaidya B, Dube D. Novel Drug delivery systems, in: Lachman’s Theory and practices of industrial pharmacy, CBS Publishers and distributors, New Delhi, 2013.

5.       Vaidya B. Solid Lipid Nanoparticles, In: Nanocarriers: Theory, principles and application, Pharma Book Syndicate Hyderabad, 2013

 

Foreign Books

1.       Vyas SP, Vaidya B, Tiwari S. Novel carrier adjuvants for DNA vaccination, In: DNA Vaccines: Types, Advantages, and Limitations, Nova science publishers, Hauppauge NY USA, 2011.

2.       Vaidya B, Vyas SP. Designing nanocarriers for the effective treatment of cardiovascular diseases. In: Clinical Nanomedicine: from bench to bedside. Panstanford Publishers Singapore. 2011.

3.       Vaidya B. and Vaidya S. Polymeric biodegradable particles for the delivery of protein therapeutics. In: Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Taylor and Francis, New York NY USA, 2013

 

    

 

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