SPEAKER: Eva Miadokova D.Sc.  

Comenius University,

Faculty of Natural Sciences,

Department of Genetics,

Bratislava, Slovakia

BIOSKETCH

Research Interests: antigenotoxicity, anticarcinogenesis, apoptosis, bioprotectivity, biotherapy, cell cycle, DNA repair

Scientific Contributions:

• the mechanism of action elucidation of natural phytochemicals with potential and efficacy for tumor chemoprevention and antineoplastic bio-therapy
• the enhancement of direct stimulatory effect of natural substances on the cytostatic/therapeutic effect of drugs
• utilization of synergistic effect obtained after the combined application of bio-modulators with cytostatics for the synthetic drug dose reduction and elimination of some side cytostatic effects

Scientific and Professional Activities:

• principal investigator of many international and domestic research grants
• member of Integrated Project and Network of Excellence
• field editor Neuroendocrinology Letters (Stockholm, Sweden)
• field editor Interdisciplinary Toxicology (Bratislava, Slovakia)
• member of Editorial Board Algological Studies Internacional Journal of Phycological Research (Stuttgart, Germany)

Grants Awarded:

• 5th frame programme – ALGINET
• Bilateral Scientific and Technological cooperation with the Bulgarian Academy of Sciences
• Grants from Slovak Research and Development Agency (SRDA)
• Grants Scientific Grant Agency of the Ministry of Education of the Slovak Republic (ME SR) and of Slovak Academy of Sciences (SAS).

Selected Publications:

Miadokova, E., Vlckova, V., Duhova, V., Trebaticka, M., Garajova, L., Grolmus, J., Podstavkova, S., Vlcek, D.: Effects of supercypermethrin, a synthetic developmental pyrethroid,on four biological test systems. Mutation Res. 280: 161-168, 1992.

Miadokova, E., Masterova, I., Vlckovc, V., Duhova, V., Toth ,J.: Antimutagenic potential of homoisoflavonoids from Muscari racemosum. J. Ethnopharmacology. 18: 381-386, 2002.

Cipak, L, Rauko, P., Miadokova, E., Cipakova, I., Novotny, L.: Effects of flavonoids on cis-platin-induced apoptosis of HL-60 and L1210 leukemia cells. Leuk. Res. 27: 65-72, 2003.

Cipak ,L., Grausova, L., Miadokova E., Novotny, L., Rauko P.: Dual activity of tripertenoids: apoptotic versus antidifferentiation effects. Arch. Toxicol. 80: 429-435, 2006.

Miadokova, E., Nadova, S., Vlckova, V., Duhova ,V., Kopaskova, M., Cipak, L., Rauko, P., Mucaji, P., Grancai, D.: Antigenotoxic effect of extract from Cynara cardunculus L.: Phytother. Res. 22(1): 77-81, 2008.

Kogan, G., Pajtinka, M., Babincova, M., Miadokova, E., Rauko, P., Slamenova, D., Korolenko,T.: Yeast cell wall polysaccharides as antioxidants and antimutagens: Can they fight cancer? Neoplasma 55(5): 387-393, 2008.

Miadokova, E., Chalupa, I., Vlckova,V., Sevcovicova, A., Nadova, S., Kopaskova, M., Hercegova, A., Gasperova, A., Alfoldiova, L., Komjatiova, M., Csanyiova, Z., Galova, E., Cellarova, E., Vlcek, D.: Genotoxicity and antigenotoxicity evaluation of non-photoactivated hypericin. Phytother. Res. 24: 90–95, 2010.

Hudecova, A., Hasplova, K., Miadokova, E., Magdolenova, Z., Rinna, A., Collins, A.R., Galova, E., Vaculcikova, D., Gregan, F., Dusinska, M.: Gentiana asclepiadea protects human cells against oxidation DNA lesions. Cell Biochem. Funct. 30(2): 101-107, 2012

Hudecova, A., Kusznierewicz, B., Hasplova, K., Huk, A., Magdolenova, Z., Miadokova, E., Gálova, E., Dusinska, M.: Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage. Food Chem Toxicol. 50(9): 3352-3359, 2012.

Hudecová, A., Kusznierewicz, B., Rundén-Pran, E., Magdolenová, Z., Hasplová, K., Rinna, A., Fjellsbo. L.M., Kruszewski, M., Lankoff, A., Sandberg, W.J., Refsnes, M., Skuland, T., Schwarze, P., Brunborg, G., Bjoras, M., Collins, A., Miadokova, E., Galova, E., Dusinska, M.: Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea. Mutagenesis. 27(6): 759-769, 2012.

Hasplova, K., Hudecova, A., Magdolenova, Z., Bjoras, M,. Galova, E., Miadokova, E., Dusinska, M.: DNA alkylation lesions and their repair in human cells: modification of the comet assay with 3-methyladenine DNA glycosylase (AlkD). Toxicol Lett. 208(1): 76-81, 2012.